Figure 3

Components of the RIG-I and TLR3/TLR4 pathway activate IFN-β promoter in HEK293 cells. HEK293 cells were transfected with expression constructs (0.1 μg) for intracellular signaling molecules as shown in the figure and IFN-β reporter plasmid (0.1 μg). IFN-β promoter activities were measured in mock and Sendai virus-infected HEK293 cell lysates. The activity of the control sample (pcDNA3) was assigned to 1.