Table 3 Evolution of NEF viral quasispecies within CTL epitopes in macaques following SIV challenge
Macaque # | sequences of epitopic peptides | SIV mac251 sequences | post-SIV challenge sequences | weeks | |
|---|---|---|---|---|---|
125 | NEF 169–178 | KTFGWLWKLV | KTFGWLWKLV 11/11 | KTFGWLWKLV 10/10 | 35 |
105 | NEF 128–136 | GLEGIYYSA | GLEGIYYSA 9/11 GLEGIYYST 2/11 | GLEGIYYSA 5/9 GLEGIYYST 4/9 | 40 |
127 | NEF 116–126 | AIDMSHFIKEK | AIDMSHFIKEK 11/11 | AIDMSHFIKEK 6/10 AIDMSHL IKEK 4/10 | 40 |
129 | NEF 128–136 | GLEGIYYSA | GLEGIYYSA 9/11 GLEGIYYST 2/11 | GLEGIYYST 9/9 | 35 |
|  | NEF 169–178 | KTFGWLWKLV | KTFGWLWKLV 11/11 | KTFGWLWKLV 9/9 |  |
|  | NEF 201–211 | SKWDDPWGEVL | SKWDDPWGEVL 9/11 SR WDDPWGEVL 1/11 SQ WDDPWGEVL 1/11 | SKWDDPWGEVL 2/9 AQ WDDPWGEVL 3/9 AQ WDDPWGEI L 1/9 A KWDDPWGEVL 2/9 SR WDDPWGEVL 1/9 |  |
|  | NEF211–219 | LAWKFDPTL | LAWKFDPTL 10/11 LAWKFDPA L 1/11 | LAWKFDPTL 2/9 LAWR FDPTL 3/9 LAWKFDS TL 3/9 LAWR FDS TL 1/9 |  |
109 | NEF 101–110 | SVRPKVPLRA | P VM PR VPLRT 8/11 P VMPR VPLRA 1/11 SVRPKVPLRT 1/11 SMK PR VPLRT 1/11 | P VM PR VPLRT 9/9 | 41 |
|  | NEF 116–126 | AIDMSHFIKEK | AIDMSHFIKEK 11/11 | AIDMSHFIKEK 9/9 |  |
|  | NEF 128–136 | GLEGIYYSA | GLEGIYYSA 9/11 GLEGIYYST 2/11 | GLEGIYYSA 9/9 |  |
|  | NEF 169–178 | KTFGWLWKLV | KTFGWLWKLV 11/11 | KTFGWLWKLV 9/9 |  |
|  | NEF 215–225 | FDPTLAYTYEA | FDPTLAYTYEA 10/11 FDPA LAYTYEA 1/11 | FDPTLAYTYEA 9/9 |  |
| Â | GAG -275 | WIQLGLQKCV | WIQLGLQKCV 11/11 | ND | Â |