Characterization of the IFN-γ T-cell responses to immediate early antigens in humans with genital herpes

Table 6 T-cell responses for subjects grouped by HSV-1/HSV-2 serostatus. Data is the same as Table 2 but subjects have been organized into groups based on their HSV-1 and HSV-2 serostatus. For CD4 responses, the total number of ELISPOTs (E#) for each peptide pool of that group is included. Total number of CD4 ELISPOTs for each protein from each group were used to generate a ratio of the ELISPOTs measured in HSV-1/HSV-2 double positives and HSV-2 single positives. Values were adjusted to compensate for the different number of subjects per group

HSV-2 SINGLE POSITIVIES
CD4 Responses														CD8 Responses
Patient	ICP27	ICP22	ICP0–1	ICP0–2	ICP0–3	ICP4–1	ICP4–2	ICP4–3	ICP4–4	ICP4–5	ICP4–6	VP22	gD		ICP0	ICP4	VP22
6	W	W		S		W	W		W			S	S
8		W	S					W		W		W	W		P
9	W			S		W		S		S		W	W		P	P
11	W	W					W	W				S	S
12		S	S		W		W	W		S		S	S
14													S				P
15		W	S					W		W	W	S	S				P
16			W					S				W	S
E#	37	87	133	62	21	14	18	135	62	69	8	309	394
HSV-2/HSV-1 DOUBLE POSITIVES
CD4 Responses														CD8 Responses
Patient	ICP27	ICP22	ICP0–1	ICP0–2	ICP0–3	ICP4–1	ICP4–2	ICP4–3	ICP4–4	ICP4–5	ICP4–6	VP22	gD		ICP0	ICP4	VP22
1	S	S						W	W	W	W	S	W
2			W					S		S		W	S				P
3	W			S					S	S	S	S	S			P
5	W	W			S				W				S		P		P
13					S							S	S
18		W		S			W	W	S		S	S	W			P
E#	64	45	23	96	96	0	9	128	96	109	64	261	254
HSV-1 SINGLE POSITIVES
CD4 Responses														CD8 Responses
Patient	ICP27	ICP22	ICP0–1	ICP0–2	ICP0–3	ICP4–1	ICP4–2	ICP4–3	ICP4–4	ICP4–5	ICP4–6	VP22	gD		ICP0	ICP4	VP22
7								S		W
10					W					S
17								S		S
					7			152		130
	ICP27	ICP22	ICP0	ICP4	VP22	gD
	2.4	0.68	1.3	1.5	1.1	0.86	Ratio of double positive/HSV-2 single positive

ISSN: 1743-422X