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Figure 3 | Virology Journal

Figure 3

From: The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin

Figure 3

Effect of CDM on the antiviral action exerted by IFNs. Vero cells were treated with 100 IU/ml of IFN-α, 100 IU/ml IFN-γ or a combination of both for 16 h before infection with HSV-2 MS. After virus adsorption cells were re-fed with fresh cytokines which remained until 24 h p.i.. Different CDM treatments were performed: (a) Cells were treated with CDM 2h prior to interferon induction and then removed; (b) CDM was added simultaneously with IFN and remained only for 16 h before infection; (c) CDM was added after virus infection and remained until virus harvest; (d) CDM was added with IFN 16 h before infection, re-added after infection and remained to virus harvest. Average fold inhibition was calculated as (average viral titers in vehicle-treated/average viral titers in IFN-treated).

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Virology Journal

ISSN: 1743-422X