Skip to main content
Figure 1 | Virology Journal

Figure 1

From: The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin

Figure 1

Effect of IFN-α and IFN-γ on HSV replication. Vero cells were treated with (■) vehicle or 100 IU/ml each of (●) IFN-α, (▲) IFN-γ or (▼) IFN-α and IFN-γ 16 h before infection with HSV-2 strain (a, e) MS, HSV-2 strain (b, f) G, HSV-1 strain (c, g) KOS or HSV-1 strain (d, h) F at a MOI of 1 PFU per cell. Supernatants were harvested on the indicated days p.i. and viral titers were determined by plaque assay as described in Material and Methods. (e-h) Average fold inhibition in viral replication observed in cells treated 100 IU/ml each of ()IFN-α, (□) IFN-γ or (■) IFN-α and IFN-γ was calculated as (average viral titers in vehicle-treated/average viral titers in IFN-treated). One-way ANOVA followed by Tukey's post hoc t test confirmed that the differences were significant (p < 0.001).

Back to article page

Virology Journal

ISSN: 1743-422X