|  | ACUTE INFECTION | REACTIVATION |  | ||
---|---|---|---|---|---|---|
Mouse strain | Virusa | Inoculumb | Survivalc | Viral spread to L7 cellsd | Virus in TG on Day 14e | Viral genomes per TGf |
Strain 129 | KOS | 2 × 105 | 100% (n = 15) | 11/16 | 14/16 | 3.0 × 105 |
Strain 129 | 0--GFP | 2 × 105 | 100% (n = 15) | 0/16 | 0/16 | 1.3 × 105 * |
ifngr -/- | 0--GFP | 2 × 105 | 100% (n = 25) | 0/38 | 0/38 | 1.2 × 105 * |
ifnar -/- | 0--GFP | 2 × 105 | 100% (n = 21) | 0/16 | 2/16 | 3.5 × 105 |
rag2 -/- ifnar -/- | 0--GFP | 2 × 104 | 0% (n = 11) | NDh | ND | ND |
ifnar -/- ifngr -/- | 0--GFP | 2 × 104 | 21% (n = 14) | 0/6 | 0/6 | ND |
stat1 -/- | 0--GFP | 2 × 104 | 50% (n = 50) | 0/22 | 2/22 | 1.8 × 105 |