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Table 2 Effect of interferon receptors versus Stat 1 on HSV-1 shedding and the survival of infected mice.

From: ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency

   Viral titers per eye on day 3 p.i.c Survival
Virusa Mouse strainb   Frequencyd Duration (days)e
  wild-type 1.8 ± 0.3 100% > 60
  rag2 -/- 1.5 ± 0.4 0% 18 ± 0.5
  ifngr -/- 1.8 ± 0.5 100% > 60
  ifnar -/- 2.8 ± 0.3 50% 11 ± 1
KOS-GFP (ICP0+) ifnar -/- ifngr -/- 3.6 ± 0.1* 0% 5.2 ± 0.1
  stat1 -/- 4.3 ± 0.1* 0% 8.1 ± 0.3
  rag2 -/- stat1 -/- 4.0 ± 0.2* 0% 8.6 ± 0.2
  rag2 -/- ifnar -/- 4.2 ± 0.2* 0% 7.9 ± 0.2
  wild-type 1.1 ± 0.6 center100% > 60
  rag2 -/- 0.7 ± 0.5 100% > 60
  ifngr -/- 1.4 ± 0.4 100% > 60
  ifnar -/- 2.2 ± 0.1 100% > 60
0--GFP (ICP0-) ifnar -/- ifngr -/- 3.4 ± 0.3* 16% 11 ± 1
  stat1 -/- 4.4 ± 0.1* 50% 11 ± 1
  rag2 -/- stat1 -/- 3.4 ± 0.2* 0% 11 ± 1
  rag2 -/- ifnar -/- 3.8 ± 0.2* 0% 10 ± 1
  1. a Mice were inoculated with 2 × 105 pfu per eye of HSV-1 strain KOS-GFP or 0--GFP.
  2. b The relationship of the genotype and phenotype of these mice is defined in Table 1.
  3. c The mean ± standard error of the mean of the logarithm of infectious viral titers recovered from the ocular tear film of mice at day 3 p.i. (n = 6 per group).
  4. d The percentage of mice that survived until day 60 p.i.
  5. e The mean ± standard error of the mean duration of survival of those mice that survived for less than 60 days after inoculation with HSV-1. Groups of mice in which no deaths were recorded were sacrificed on day 60 p.i., and their duration of survival is indicated as "> 60."
  6. * p < 0.05 that viral titers on day 3 p.i. were equivalent to those recovered from wild-type mice infected with the same virus, based on one-way ANOVA and Tukey's post hoc t-test.
  7. p < 0.05 that the duration of survival was equivalent to the duration of survival of rag2-/- (lymphocyte-deficient) mice infected with the same virus, based on one-way ANOVA and Tukey's post hoc t-test.