Loss of IFN-α/β receptors or Stat 1 impairs an innate host response that represses KOS-GFP and 0--GFP at the site of inoculation. Mice were inoculated with 2 × 105 pfu per eye of A. HSV-1 strain KOS-GFP, or B. the ICP0- virus, 0--GFP. GFP fluorescence was recorded in the right eyes of strain 129 mice, rag2-/- mice (lymphocyte-deficient), ifngr-/- mice (IFN-γ receptor-null), ifnar-/- mice (IFN-α/β receptor-null), ifnar-/- ifngr-/- mice, stat1-/- mice, rag2-/- stat1-/- mice, and rag2-/- ifnar-/- mice. Representative photographs are shown of GFP fluorescence in the virus-infected eye of one mouse per group photographed over time at 36, 60, and 84 hours p.i. (4× magnification; 39 ms exposure for KOS-GFP; 63 ms exposure for 0--GFP).