Figure 1

Diagram of the HRSV F protein. A linear representation of the HRSV F precursor protein (A2 strain) is shown. Amino acid positions of individual domains are indicated with residues numbered in the context of the full-length coding region. Disulfide linked F1 & F2 subunits are delineated with arrows. The furin mediated cleavage sites are indicated by filed arrowheads. The intervening cleavage fragment is indicated as a gray box. Positions of the individual cysteine residues are depicted as asterisks. Asparagine residues (N116 and N126) which are sites of N-linked glycosylation are represented with circles. The site of palmitoylation at cysteine residue 550 is depicted as a jagged line. SP = signal peptide; f = fusion peptide; HR1 = heptad repeat 1; HR2 = heptad repeat 2; TM = transmembrane region. Figure adapted from [5].