Table 2 Subcellular localization prediction of vaccinia virus proteins
From: Predicting the subcellular localization of viral proteins within a mammalian host cell
Gene | SwissProt Accession | PSLT predictionsa | Literature annotations | Localization References | Closest human homologueb | BLAST e-value |
|---|---|---|---|---|---|---|
A34R | P21057 | PM | Golgi | [45] | C-type lectin (NP_072092) | 0.02 |
A38L | P21061 | PM | PM | [46] | CD47 antigen (NP_001768) | 3E-22 |
A39R | P21062 | Secreted and PM | Secreted | [47] | semaphorin 7A (NP_003603) | 1E-30 |
A40R | P21063 | PM | PM | [48] | lectin-like receptor (NP_031359) | 2E-9 |
B13R | P20841 | Secreted | Cytoplasmic | [49] | plasminogen activator inhibitor-2 (NP_002566) | 5E-7 |
B15R | P21116 | Secreted and PM | PM or secreted | [50] | interleukin 1 receptor (NP_775465) | 4E-32 |
B18R | P21076 | Cytosolic and nuclear | Secreted and PM | [51] | Ankyrin 3 isoform 1 (NP_066267) | 1E-9 |
B5R | P21115 | Secreted and PM | PM and Golgi | [45,52,53] | coagulation factor XIII B (NP_001985) | 6E-17 |
C12L | P20531 | Secreted | Secreted | [54] | serine proteinase inhibitor (NP_002965) | 4E-47 |
C2L | P21037 | Nuclear and cytosolic | Cytoplasmic | [55] | kelch-like 10 (NP_689680) | 1e-024 |
D8L | P20508 | PM | PM | [56] | carbonic anhydrase XIII (NP_940986) | 8E-35 |
A45R | P21132 | Cytosolic | Cytoplasmic | [3] | superoxide dismutase 1 (NP_000445) | 3E-6 |
D4R | P20536 | Nuclear and mitochondrial | Cytoplasmic | [56] | - | > 0.1 |
D6R | P20634 | Nuclear | Perinuclear | [58] | hypothetical protein (NP_060139) | 0.027 |
E9L | P20509 | Nuclear | Cytoplasmic | [57] | polymerase alpha (NP_058633) | 9E-19 |
E3L | P21081 | Nuclear | Nuclear | [59] | adenosine deaminase (NP_001102) | 4E-6 |
F17R | P68454 | Cytosolic and nuclear | Cytoplasmic | [60] | - | > 0.1 |
F4L | P20493 | Cytosolic | Cytoplasmic | [57] | ribonucleotide reductase M2 (NP_001025) | 1E-143 |
A56R | P20978 | PM | PM | [61] | dentin matrix acidic phosphoprotein (NP_004398) | 0.015 |
K1L | P20632 | Cytosolic and nuclear | Cytoplasmic | [62] | ankyrin 2 (NP_001139) | 1E-9 |
K2L | P20532 | Secreted | Extracellularly associated with infected cell | [63] | plasminogen activator inhibitor-1 (NP_000593) | 3E-35 |
M1L | P20640 | Cytosolic and nuclear | Cytoplasmic | [64] | ankyrin 3 (NP_066267) | 4E-13 |
C11R | P20494 | PM and secreted | Secreted | [65] | epiregulin (NP_001423) | 2E-10 |