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Table 1 Replication of UL27 deletion mutants in retinal tissue implants in SCID-hu mice.

From: Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice

Virus

Days post infection

 

7

16

28

42

AD169 (ATCC)a

3.0 ± 0.58 (4/12)b

3.5 ± 1.3 (5/12)

3.7 ± 0.87 (10/12)

4.1 ± 1.1 (7/14)

T2092-1-1-7

0 ± 0 (0/12)

0 ± 0 (0/12)

0 ± 0 (0/12)

3.1 ± 0.17 (4/12)

AD169 RVc

2.6 ± 0.17 (4/12)

3.6 ± 1.2 (7/12)

3.1 ± 0.52 (4/12)

3.2 ± 0.74 (3/14)

ΔUL27BAC

0 ± 0 (0/12)

3.6 ± 0.87 (5/12)

3.0 ± 0.45 (5/12)

3.4 ± 0.61 (5/14)

1/3ΔUL27BAC

0 ± 0 (0/12)

2.6 ± 0.21 (2/12)

3.5 ± 0.04 (3/12)

3.6 ± 0.52 (6/14)

  1. a. AD169 (ATCC) is the isogenic strain of AD169 for T2092-1-1-7.
  2. b. Number shown is the average titer in units of log10PFU/g of tissue ± the standard deviation with the number of positive animals/the number of inoculated animals shown in parentheses.
  3. c. AD169 RV is the isogenic strain of AD169 for UL27Δ and UL27Δ1/3.