HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers

Table 4 Major sequence polymorphisms found in the groups studied.

Amino acid-Position-mutation	Frequency (%)	Consensus sequences
L5M	28	Group A: 17 recovered patients
Q8K	22
T12A	36
S29P	38
S31P	30
S33P	30
V37I	33
P40S	30	Group B: 7 acute-chronic patients MAARLCCQLDP-RDVLCLRPVGAESRGRSLSGSLGAVPPPSPSAVPADDGSHLSLRGLPV CSFSSAGPCALRFTSARRMETTVNAPRSLPTVLHKRTLGLSGRSMTWIEDYIKDCVFKDW EELGEEIRLKVFVLGGCRHKLVCSPAPCNFFTSA*
D48N	25
R87W	30
R103W	33
T106P	25	Group B: 32 chronic patients MAARLCCQLDPTRDVLCLRPVGAESRGRSLSGSLGAVPPPSPSAVPADDGSHLSLRGLPV CSFSSAGPCALRFTSARRMETTVNAPRSLPTVLHKRTLGLSGRSMTWIEDYIKDCVFKDW EELGEEIRL- - FVLGGCRHKLVCSPAPCNFFTSA*
D110E	33
K130M	24
V131I	27
Deleted nt	8	Consensus Deletion group 8 bp MAARLCCQLDPTRDVLCLRPVGAESRGRSLSGSLGAVPPPSPSAVPADDGSHLSLRGLPV CSFSSAGPCALRFTSARRMETTVNAPRSLPTVLHKRTLGLSGRSMTWIEDYIKDCVFKDW EELGEEIRLNIRRL*
390-397
end codon
135 aa

Hyphens in the consensus sequence represent the amino acid polymorphism associated with the left column. The predicted consensus amino acid sequence was obtained with Bioedit Software from the nucleotide sequence of the sample study.

ISSN: 1743-422X