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Table 7 Predicted amino acid residues in the gp41 cytoplasmic tail that differ in the indicated viruses. Residues found only in the microglia-passage derived SIVmac182 stock, and/or in the resulting virus released from monkey 225 and 321 microglia, are in bold; italics further indicated residues found in the microglia virus but not SIVmac182. For amino acid 747, a mixed sequence was present in SIVmac182 capable of encoding either amino acid listed. Population-based sequencing was performed on the SIVmac251, SIVmac182, 225 microglia, and 321 microglia viral stocks. SIVmac239 is provided for reference.
From: Development and characterization of positively selected brain-adapted SIV
| 695 | 737 | 741 | 747 | 748 | 751 | 758 | 760 | 785 | 794 | 802 | 808 | 821 | 831 | 837 | 850 | 858 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SIVmac239 (clone) | V | I | P | E | S | R | G | S | S | V | L | T | T | H | V | G | R |
| SIVmac251 (stock) | V | I | P | E | S | G | S | S | S | A | L | A | T | Q | G | G | G |
| SIVmac182 (stock) | I | I | Q | G/E | G | G | G | R | S | V | F | T | T | Q | G | R | R |
| 225 microglia | I | T | Q | G | G | G | G | R | N | V | F | T | A | Q | G | R | R |
| 321 microglia | I | T | Q | G | G | G | G | R | N | V | F | T | A | Q | G | R | R |
