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Table 2 PCP-motifs identified for the flavivirus NS3 proteases, using the sequence of DV-2 NS3 to indicate location and representative sequence. The catalytic residues (H51, D75, S135) are shadowed; residues in the substrate interaction pocket [28] are bold, and areas that are part of known T-cell epitopes are underlined.

From: Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses

Motif No.

PCP-motifs

1

2 GVLWDVPSP 10

2

29 GILGYSQI GAG 39

3

43 EGTFHTMWHV TRGA 56

4

73 KK D LISY GGGW 83*

5

95 VQVLALEPG 103

6

133 G T SG SP 138**

7

148 GLYGNG 153

8

159 GAY VS AIAQ 167

  1. *C-terminal end, cytotoxic T-cell epitope AA 71–79 [40].
  2. **N-terminal end of 11 mer T-cell activating peptide [5].