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Table 2 PCP-motifs identified for the flavivirus NS3 proteases, using the sequence of DV-2 NS3 to indicate location and representative sequence. The catalytic residues (H51, D75, S135) are shadowed; residues in the substrate interaction pocket [28] are bold, and areas that are part of known T-cell epitopes are underlined.

From: Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses

Motif No. PCP-motifs
1 2 GVLWDVPSP 10
2 29 GILGYSQI GAG 39
3 43 EGTFHTMWHV TRGA 56
4 73 KK D LISY GGGW 83*
5 95 VQVLALEPG 103
6 133 G T SG SP 138**
7 148 GLYGNG 153
8 159 GAY VS AIAQ 167
  1. *C-terminal end, cytotoxic T-cell epitope AA 71–79 [40].
  2. **N-terminal end of 11 mer T-cell activating peptide [5].