In vitro propagation of HCV in cultured cells. Morphology of neuronal precursor cells infected with HCV. (A) T (telencephalon, suspension cells that grow in clumps and also can adhere to plastic), and (B) M (metencephalon, primarily adherent cells that develop neuronal processes). (C) Freshly transformed B-cells co-cultured with HCV infected macrophages. None of these cells have definitive cytopathic effects when compared with uninfected cells.