Figure 4

CYP-treated BALB/c mice produce higher levels of Th1 and Th2 cytokines. Mice were infected with RSV alone or were treated with cyclophosphamide prior to infection. The third group of mice received no virus (PBS only) as control. Animals were sacrificed on day 5 and their lungs removed. Whole lung homogenates were prepared and cyrtokines were measured by ELISA. Results are given as mean ± SEM (n = 4 for each group). (A) CYP-pretreated mice produce higher IL-10 in the lungs. (‡ P < 0.05 vs. PBS). (B) IL-12 was higher in CYP-treated mice. (§ P < 0.01 vs. PBS. * P < 0.05 vs. RSV). (C) IFN-γ was higher in CYP-treated mice. (* P < 0.05 vs. RSV; ‡ P < 0.05 vs. PBS).