Figure 1

(A) CYP increases RSV titer in the lungs of BALB/c mice. Mice were treated with CYP (100 mg/kg, i.p.) or PBS and 5 days later infected with RSV (50 μl i.n. twice, 10⁶ PFU/ mouse). Animals were sacrificed on day 4 and RSV titers were measured in whole lung homogenates by RSV plaque assay. (n = 4 for each group; § P < 0.01 vs PBS group). (B) Cyclophosphamide affects body weight. Mice (n = 4) were infected with RSV alone or were treated with CYP (100 mg/kg i.p.) prior to infection. Body weights were measured on day 1, 5, 10, 15, and 22 after treatment. Bars represent means ± SEM. (* P < 0.05; †. P < 0.01 vs RSV); ‡ P < 0.05; § P < 0.01 vs control).