Table 1 Number and percent of HIV positive pregnant women and infants assigned to the different AIDS Clinical Trails Group (ACTG) protocols or to zidovudine (ZDV)
ACTG Protocol # | Number of women (%) | Dose and frequency |
|---|---|---|
185 [38] | 16 (37.2) | Mother: ZDV according to 076 protocol [3] plus anti-HIV immune serum globulin (HIVIg) or immune globulin (Ig) (200 mg/kg) every 28 days followed by 1.0 mg/kg/hr continuous infusion during labor and delivery. Infant: HIVIg (200 mg/kg) or normal Ig within 12 hrs of birth plus oral ZDV syrup (2.0 mg/kg) every 6 hours after birth (beginning within 8–12 h) and continuing for 6 weeks. |
249 [39] | 4 (9.3) | Mother: Didanosine (ddi) IV (1.6 mg/kg) on day one, during pregnancy, followed by an oral dose (200 mg) one week after the initial dose. Oral ddi is then administered every 12 hrs until labor starts and every 12 hrs after delivery until 6 weeks post-partum. During labor and delivery patients receive a loading dose followed by continuous infusion. Infant: Oral ZDV syrup (2.0 mg/kg) every 6 hours after birth and continuing to week 6. |
250 [40] | 5 (11.6) | Mother: ZDV plus Nevirapine (200 mg/kg) single dose during labor. Infant: Oral ZDV syrup (2.0 mg/kg) every 6 hours after birth and continuing to week 6 plus single dose of Nevirapine (2 mg/kg) after birth. |
296 [41] | 3 (7.0) | Mother: ZDV as in protocol 185. Infant: Oral ZDV syrup (2.0 mg/kg) every 6 hours after birth and continuing to week 6. |
316 [42] | 9 (20.9) | Mother: Nevirapine (200 mg oral dose) or the corresponding placebo during delivery plus ZDV (as in 076). Infant: ZDV perinatal prophylaxis (2.0 mg/kg) plus single 2.0 mg/kg oral dose of Nevirapine or Nevirapine placebo administered between 48 and 72 hrs of life. |
324 [43] | 3 (7.0) | Mother: ZDV before and after delivery as is usual but oral administration of ZDV (300 mg) every 3 hrs, 3 doses total during delivery. Infant: Oral ZDV syrup (2.0 mg/kg) every 6 hours after birth and continuing to week 6. |
332 [44] | 1 (2.3) | Mother: Stravudine (d4T, 30–40 mg) during pregnancy and 0.05 mg/kg/hr during delivery in combination with 3TC 150 mg followed by 150 mg during delivery. Infant: Stravudine (d4T, 1 mg/kg) single dose on day 35–42, in combination with 3TC (2.0 mg/kg/dose). |
ZDV [3] | 2 (4.7) | Mother: ZDV (2.0 mg/kg) every 28 days followed by 1.0 mg/kg/hr continuous infusion during labor. Infant: Oral ZDV syrup (2.0 mg/kg) every 6 hours after birth and continuing to week 6. |