IFN Treatmenta (da + db) | IC90 Dab | IC90 Dbb | interaction indexc |
---|
IFN-α + IFN-γ | 300 IU/ml | 30 IU/ml | 0.05 ± .03 |
IFN-β + IFN-γ | 100 IU/ml | 30 IU/ml | 0.04 ± .01 |
- aHFFs were treated 12 h prior to infection with various combinations of type 1 IFNs (IFN-α or IFN-β) and type II IFN (IFN-γ).
- bDa and Db are the concentrations of each IFN separately that inhibit HCMV plaque formation on HFFs by 90% (IC90).
- c Interaction index is a measure of the divergence between the amounts of IFNs that are observed to produce an inhibitory effect in combination (da + db) and the amounts that would achieve the same effect separately (Da and Db). Indexes less than 1 indicate synergy, indexes greater than 1 indicate antagonism and indexes equal to 1 indicate additivity.