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Table 2 Degree of antiviral interaction between IFN-α/β and IFN-γ

From: Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma

IFN Treatmenta (da + db)

IC90 Dab

IC90 Dbb

interaction indexc

IFN-α + IFN-γ

300 IU/ml

30 IU/ml

0.05 ± .03

IFN-β + IFN-γ

100 IU/ml

30 IU/ml

0.04 ± .01

  1. aHFFs were treated 12 h prior to infection with various combinations of type 1 IFNs (IFN-α or IFN-β) and type II IFN (IFN-γ).
  2. bDa and Db are the concentrations of each IFN separately that inhibit HCMV plaque formation on HFFs by 90% (IC90).
  3. c Interaction index is a measure of the divergence between the amounts of IFNs that are observed to produce an inhibitory effect in combination (da + db) and the amounts that would achieve the same effect separately (Da and Db). Indexes less than 1 indicate synergy, indexes greater than 1 indicate antagonism and indexes equal to 1 indicate additivity.