Figure 3From: Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animalsVariant populations present in plasma of infant macaques one week after oral challenge with SIVmac251-5/98. RT-PCR and HMA analysis was performed on replicate samples to confirm reproducibility of the results. Three main transmission patterns were observed, labeled A (multiple variants; diverse virus population), B and C (one major homoduplex (Ho) with a few faint heteroduplexes (He); relatively homogenous virus population). One infant (31833) harbored a plasma virus population that had elements of both transmission patterns A and C. SIV251 V.S. indicates the SIVmac251-5/98 virus stock.Back to article page