Figure 1
Effect of RNApol fidelity on replication. Each replication cycle may produce either wild-type (Wt) or variant (Mt) copies of parental template in a ratio determined by polymerase fidelity. If HCV RNApol Mu is 10-5 mutations per base RNA synthesized, Mt:Wt ratio at G1 is ~9:1, by G3 unmutated parental genome is 6.8 × 10-4of total virus population, and by G20 7.5 × 10-22