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Figure 2 | Virology Journal

Figure 2

From: Difference in cytokine production and cell cycle progression induced by Epstein-Barr virus Lmp1 deletion variants in Kmh2, a Hodgkin lymphoma cell line

Figure 2

Cytokine expression is differently regulated by LMP1 variants. Cytokines expressed by KMH2-pRT-LMP1 cells (non-induced, WT, del30 and del69) were intracellularly stained and detected by flow-cytometry 24 h after induction of LMP1 expression. The percentages of cells expressing (a) IFN-γ, (b) IL-6, (c) RANTES/CCL5, (d) TNF-β and (e) TNF-α were compared. All cytokines were significantly more expressed in LMP1 expressing cells compared to non-induced cells with an ANOVA analysis (of note that expression of IFN-γ was significantly higher in KMH2-pRT-del30-LMP1 cells compared to the control unstimulated KMH2 cells with an ANOVA analysis followed by a Dunnett post-test). Supplemental data showing LMP1 and cytokine labeling dot plots are provided as Additional file 1.

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Virology Journal

ISSN: 1743-422X