Table 9 Molecular changes associated with anti-herpetic drugs resistance in thymidine kinase (TK) and DNA polymerase (DNA pol) genes of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) according to amino acid mutations, stop codon and nucleotide insertion or deletion reported in the literature[29–34]
From: Diagnosis of genital herpes simplex virus infection in the clinical laboratory
Gene | Drug | Aminoacidmutationsa | Stop codona | Nucleotide insertion/deletionb | Association of mutationsa |
|---|---|---|---|---|---|
HSV-1 TK | ACV | R51W, Y53P/D/H, D55N, G56S/V, P57H, K62N, H58R/L, G59R/Y/W, G61V, K62N, T63A/I/S, T64A/S, T65N, E83K, P84S, V87H, T103P, Q104H, H105P, Q125E/L, M128A/F, G129D, G144N/R, A156V, D162A, R163H/C, A167V, A168T, L170P, Y172C/F, P173L/R, A174P, A175V, R176Q, L178R, S181N, Q185R, V187M, A189V, G200C/D, T201P, G206R, L208H, R216C/H/S, R220C/H, R222C/H, L227F, Y239S, T245M/P, T287M, L297S, L315S, C336Y, L364P | Y53, S74, E95, T103, Q104, R176, Q250, Q261, R281, L341, C336, Q342, L364, A375 | 133-136, 153-155, 180-183, 184-187 430-436, 437-438,455-458, 460-464, 464-465, 548-553,615-619, 666-669, 853-856, 878-880, 896-900, 1061-1064 | |
HSV-2 TK | ACV | R34C, R51W, G56E, G59P, P85S, N100H, Q105P, T131P, R177W, S182D, S182N, V192M, T202A, R217H, R221H, R221C, R223H, L228I,D229H, R272V, P273S, D274R, T288M,C337Y | A28, L69, D137, Q222, Y240, T264 | 215-217, 219-222222, 439-440, 452, 467, 519-521, 551-556, 586-591, 626-628, 808-812 | R272V + P273S + D74R |
P85S + N100H + V192M | |||||
HSV-1 DNA pol | ACV | D368A, E370A, V462A, K532T, Y557S, Q570R, D581A, G597K/D, A605V, Q618H, Y696H, R700G, L702H, V714M, V715M, F716L, A719V/T, S724N,E771Q, L774F, L778M, D780N, L782I, P797T, E798K, L802F, V183M, N815L/S/T/V/Y/E, Y818C, T821M, G841S/C, R842S, S889A, F891C/Y, V892S, D907V, I922N/T, Y941H, V958L, R959H, N961K, D1070N | A719V + V904M | ||
A327T + A605V | |||||
T566A + A605V | |||||
FCV | N494S, A605V, F716L, A719V,A719T, S724N, L778M, D780N, L782I, E798K, F891C, D907V, V958L | A719V + V904M | |||
A327T + A605V | |||||
S724N + A916V | |||||
CDV | A136T, R700H, R700M, S724N, T821M, L1007H, I1028T | ||||
ACV + FCV | A605V, F716L, A719V, A719T, S724N, L778M, D780N, L782I, E798K, F891C, D907V, V958L | A719V + V904M | |||
A327T + A605V | |||||
ACV + CDV | T821M | ||||
HSV-2 DNA pol | ACV | E250Q, R628C, E678G, A724V, S725G, D785N, D912N/V | |||
FCV | S725G, S729N, L783M, D912V | ||||
ACV + FCV | S725G, D912V |