Figure 4From: Oral immunization with recombinant enterovirus 71 VP1 formulated with chitosan protects mice against lethal challengeCytokine production profiles. Splenocytes from groups of immunized mice were stimulated with recombinant VP1 protein for 72 h. Concentrations of (A) IFN-γ. (B) IL-4. (C) IL-5. (D) TGF-β in the culture supernatants were determined by ELISA. The concentration values of cytokines were expressed as mean ± SD. (* P < 0.05, ** P < 0.01).Back to article page