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Figure 4 | Virology Journal

Figure 4

From: Membrane-bound IL-12 and IL-23 serve as potent mucosal adjuvants when co-presented on whole inactivated influenza vaccines

Figure 4

CYT-IVAC immunization reduces viral lung burden following challenge. Animals vaccinated I.M. (A) or I.N. (B) were challenged with a 100LD50 dose of mouse-adapted A/PR/8/34 on day 36 following vaccination. At day 4 following challenge, animals (n = 5) were sacrificed, lung tissues were collected and flash frozen. Viral loads from homogenized lung tissue (n = 5) were determined by tissue culture infectious dose assay. Data is expressed as TCID50 per gram of lung tissue. (*p < 0.05, **p < 0.01, ***p < 0.001 compared to PBS, one way ANOVA, Bonferroni’s multiple comparison test.

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Virology Journal

ISSN: 1743-422X