Regulation of gene expression by microRNA in HCV infection and HCV–mediated hepatocellular carcinoma

Table 2 Deregulated miRNA in hepatocellular carcinoma

List of oncogenic and tumor suppressive miRNAs deregulated in hepatocellular carcinoma
Oncogenic miRNA
Name	Expression in HCC	Target	References
miR-21	Up	PTEN, SPRY2, PDCD4, RHOB, MASPIN	[80, 85, 88, 90, 94]
miR-221	Up	CDKN1B/p27,CDKN1C/p57,BMF	[98, 99, 101]
miR-222	Up	PPP2R2A	[102]
miR-17/92	Up	HSP-27	[106]
miR-30d	Up	GNAI2	[107]
Tumor suppressive miRNA
Name	Expression in HCC	Target	References
miR-122	Down	ADAM17	[113]
miR-29	Down	BCL-2, MCL-1	[116]
miR-101	Down	MCL-1, FOS	[115]
miR-139	Down	ROCK2	[123]
let-7 g	Down	C-myc, p16INK4A, COL1A2	[125, 127]

Abbreviations: PTEN phosphatase and tensin homolog, SPRY2 sprouty 2, PDCD4 programmed cell death protein 4, RHOB ras homolog gene family, member B, CDKN1B cyclin-dependent kinase inhibitor 1B, CDKN1C cyclin-dependent kinase inhibitor 1C, BMF BCL-2 modifying factor, PPP2R2A protein-coding, protein phosphatase 2A subunit B, HSP-27 heat shock protein 27, GNAI2 galphai2, ADAM17 A disintegrin and metalloprotease 17, BCL-2 B cell lymphoma 2, MCL-1 myeloid cell leukemia sequence 1, FOS v-fos FBJ murine osteosarcoma viral oncogene homolog, ROCK2 rho kinase 2, COL1A2 collagen type I alpha2.

ISSN: 1743-422X