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Figure 4 | Virology Journal

Figure 4

From: Regulation of gene expression by microRNA in HCV infection and HCV–mediated hepatocellular carcinoma

Figure 4

Role of miR-29. A. TGF-β, LPS and NF-κB stimulation leads to decreased miR-29 levels. Decreased miR-29 expression level is associated with increased collagen production leading to fibrosis. B. Increased expression of miR-29 is associated with down-regulation of two anti-apoptotic molecules, Bcl-2 and Mcl-1. Cytochrome c is released in the cytoplasm with the activation of caspases, suggesting that miR-29 may promote apoptosis through a mitochondrial pathway that involves Mcl-1 and Bcl-2. The targets are represented as blue circles, while diamond represents the protein/transcription factor. The red bars represent down-regulation and the green arrows indicate the up-regulation.

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