Release of drug (ACV or PCV) over time from MED-4750 implants maintained at 25°C for 60 days. Silicone MED-4750 implants containing either ACV or PCV (33% drug load) were incubated in 1 mL PBS that was changed daily. The quantity of each drug from each day’s sample was assayed by HPLC. Each point represents the average and standard deviation of 5 replicates (PCV) or 3 replicates (ACV). A. The entire 60-day study. B. Study days 11-60.