CRTC2 enhances HBV transcription. (A) Luciferase activity in Huh-7 cells transfected with pGL-3-ENII-luc and p-CRTC2. (B) HBV mRNA levels in Huh-7 cells transfected with 1.3× wtHBV plasmid and p-CRTC2. (C-D) The effect of CRTC2 knock down on luciferase activity (C) and HBV mRNA levels (D) in pGL-3-ENII-luc and 1.3× wtHBV plasmid-transfected Huh-7 cells, respectively. *p < 0.05.