Prediction of T-cell epitopes of hepatitis C virus genotype 5a

Table 5 Binding affinity scores of predicted epitopes and their variants to common HLA class II allele types prevalent in South Africa

Position	Predicted epitopes	Genotype of epitope	HLA II- DRB1 allele types^a
			HLA-DRB1*03:01	HLA-DRB1*04:01	HLA-DRB1*11:01	HLA-DRB1*15:01
E2
507	YCFTPSPVV	1a, 1b, 2, 3, 4, 5a, 6	+	+++	+	+++
695	NIVDTQYLY	5a	+	+++	+	+++
NS2
938	LLHLGRLTG	5a	+	++	+++	+
1025	LLAPITAYA	1a, 3, 4, 5a,	+	++	+++	++
NS3
1129	DLYLVTRHA	1a, 1b, 5a	+	+	+++	+
1131	YLVTRHADV	1a, 1b, 5a	+	+	+++	+
1391	LIFCHSKKK	1b, 2, 3, 4, 5a, 6	+	+	+++	+
1417	YYRGLDVAV	5a	+	+++	++	+
1464	FSLDPTFTI	1a, 1b, 2, 5a	+	+++	+++	+
1535	TTVRLRAYL	3, 5a, 6	+	+	+	+++
1562	FTGLTNIDA	5a	+	+++	++	+
1666	VVAALAAYC	5a	+	+	+	+++
NS4B
1774	YLAGLSTLP	1a, 1b, 2, 3, 4, 5a, 6	+	+++	+	+
1919	LIAFASRGN	1a, 1b, 2, 3, 4, 5a, 6	++	+++	+++	+++
1920	IAFASRGNH	1a, 1b, 2, 3, 4, 5a, 6	+	+	+++	+
NS5A
1994	WLQAKLLPQ	5a	+	++	+++	+
2099	YHYITGVTQ	5a	+	++	+++	++
NS5B
2450	LLRHHNLVY	1a, 3, 5a	+	++	++	+++
2579	LIVYPDLGV	2, 3, 4, 5a, 6	+	+	+	+++

^a+++ indicates high binding affinity (<50 IC₅₀nm), ++ indicates medium binding affinity (>50 IC₅₀nm, <500 IC₅₀nm), + indicates poor binding affinity (>500 IC₅₀nm).

ISSN: 1743-422X