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Table 5 Inhibition of G367R virus in MT2 cells by entry inhibitors

From: Identification of an env-defective HIV-1 mutant capable of spontaneous reversion to a wild-type phenotype in certain T-cell lines

Entry inhibitor Concentration Continuousa Withdrawal
CPEb p24 CPE p24
DS 003 2 nM 3/3c >600 ng/mld 3/3 >600 ng/mld
20 nM 1/3 variable 3/3 >600 ng/ml
200 nM 1/3 variable 3/3 >600 ng/ml
AMD3100 0.18 μM 3/3 >600 ng/ml 3/3 >600 ng/ml
18 μM 1/3 variable 3/3 >600 ng/ml
180 μM 1/3 variable 3/3 >600 ng/ml
Maraviroc 1.0 nM 3/3 >600 ng/ml 3/3 >600 ng/ml
10 nM 3/3 >600 ng/ml 3/3 >600 ng/ml
100 nM 3/3 >600 ng/ml 3/3 >600 ng/ml
  1. MT2 cells were infected by pseudotyped G367R viruses at 4-fold dilutions and grown in the presence of entry inhibitors. The cultures were then split into 2 wells at day 7 with only one of them being maintained in the presence of inhibitors.
  2. aContinuous represents the maintainance of the entry inhibitors in the cultures. Withdrawal represents drug withdrawal after 7 days of infection.
  3. bCPE = cytopathic effect.
  4. cNumbers of samples in which CPE was observed over 5 weeks after infection.
  5. devaluated during 28 days following infection. p24 values of CPE negative samples were lower than listed.
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Virology Journal

ISSN: 1743-422X