|
Entry inhibitor
|
Concentration
|
Continuousa
|
Withdrawal
|
|---|
|
CPEb
|
p24
|
CPE
|
p24
|
|---|
|
DS 003
|
2 nM
|
3/3c
|
>600 ng/mld
|
3/3
|
>600 ng/mld
|
|
20 nM
|
1/3
|
variable
|
3/3
|
>600 ng/ml
|
|
200 nM
|
1/3
|
variable
|
3/3
|
>600 ng/ml
|
|
AMD3100
|
0.18 μM
|
3/3
|
>600 ng/ml
|
3/3
|
>600 ng/ml
|
|
18 μM
|
1/3
|
variable
|
3/3
|
>600 ng/ml
|
|
180 μM
|
1/3
|
variable
|
3/3
|
>600 ng/ml
|
|
Maraviroc
|
1.0 nM
|
3/3
|
>600 ng/ml
|
3/3
|
>600 ng/ml
|
|
10 nM
|
3/3
|
>600 ng/ml
|
3/3
|
>600 ng/ml
|
|
100 nM
|
3/3
|
>600 ng/ml
|
3/3
|
>600 ng/ml
|
- MT2 cells were infected by pseudotyped G367R viruses at 4-fold dilutions and grown in the presence of entry inhibitors. The cultures were then split into 2 wells at day 7 with only one of them being maintained in the presence of inhibitors.
- aContinuous represents the maintainance of the entry inhibitors in the cultures. Withdrawal represents drug withdrawal after 7 days of infection.
- bCPE = cytopathic effect.
- cNumbers of samples in which CPE was observed over 5 weeks after infection.
- devaluated during 28 days following infection. p24 values of CPE negative samples were lower than listed.
