Figure 7

Lower levels of mTOR signaling proteins in cells expressing CyPrP^EGFPfor 24 and 48 h. Targeted secondary analyses of mTOR signaling in N2a cells expressing CyPrP^EGFP for 12, 24, or 48 h. The normalized expression levels of 10 protein kinases or substrates in each of the three biological repeats are shown by individual color bars. Each color-coded category encompasses 20% changes in the levels of expression, greater than 3 times the 6% linear changes detected by the technique. Proteins indicated by dashed lines were not analyzed. The expression levels of mTORC1 and mTORC2 represent the levels of mTOR.