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Table 5 Proviral integration within genes and active genomic regions is associated with disease status

From: HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP

Data

n

Outcome

 

In gene*

Integration sites

sHBZ: 27603 wHBZ: 45439

sHBZ vs wHBZ

OR

1.04

p value

0.007

Patients

sHBZ: 93 wHBZ: 146

sHBZ vs wHBZ

OR

1.03

p value

0.2

  1. Additional factors controlled in multiple logistic regression model: Disease status and log absolute clone abundance (per integration site) or log average absolute clone abundance (per patient).
  2. *Percent of integration sites in gene per patient in patient-level analysis.
  3. OR: Odds ratio, sHBZ: strong HBZ binder, wHBZ: weak HBZ binder.
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Virology Journal

ISSN: 1743-422X