Skip to main content

Table 4 Proviral integration within genes and active genomic regions are independently associated with disease status

From: HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP

Data

n

Outcome

 

In gene*

# H3K4me2

# H3K9me3

Integration sites

AC: 29083 HAM/TSP: 43358

AC vs HAM

OR

1.08

1.13

0.88

p value

4.2×10-5

4.8×10-7

2.1×10-6

Patients

AC: 143 HAM/TSP: 95

AC vs HAM

OR

1.12

1.14

1.0

p value

0.010

0.011

1.0

  1. Additional factors controlled in multiple logistic regression model: Host HBZ binding status and proviral load, and log absolute clone abundance (per integration site) or log average absolute clone abundance (per patient).
  2. *Percent of integration sites in gene per patient in patient-level analysis.
  3. #: Number of specified epigenetic marks within 10 Kb of integration site. Averaged per patient in patient-level analysis.
  4. OR: Odds ratio, AC: Asymptomatic carrier.