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Table 3 Conserved and variable regions of HCV in the amino acid sequences of core, NS5B among the two groups

From: Occurrence of genetic modifications in core, 5′UTR and NS5b of HCV associated with viral response to treatment

Treatment groups

Conserved amino acids positions

P value

Variable amino aqcids positions

P value

 

Core

NS5B

 

Core

NS5B

 

Group 1 (n = 75)

3, 9, 10, 15, 21, 23, 25, 28, 35, 105, 106, 123, 134, 136, 137, 142

14,18,65,120,133,141

< 0.001

24, 29, 34, 36, 38, 39, 41, 65, 72, 85, 112,141, 151

35, 43, 44,47, 48, 51, 59, 62, 65, 68, 70, 87, 89, 95, 102, 107, 112, 118, 120, 129, 221, 240, 256

0.002

Group 2(n = 75)

3, 7, 9, 25, 28, 35, 106, 165, 205

13, 18, 24, 67, 85, 109, 120, 134, 143, 154, 153

< 0.001

23, 29, 35, 37, 38, 41, 43, 54, 56, 67, 72, 78, 85, 105, 112, 120, 135, 141, 156

26, 35, 48, 95, 105, 109, 108, 114, 118, 132, 143, 154, 165, 163, 172, 187, 201, 221, 240, 289, 267,256

< 0.03