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Table 1 Genetic diversity of all the three genomic regions (5′ UTR, core and NS5B) of HCV isolates for both treatment groups

From: Occurrence of genetic modifications in core, 5′UTR and NS5b of HCV associated with viral response to treatment

Factors

5′ UTR

Core

NS5B

Group 1 (n = 75)

Group 2 (n = 75)

P Values

Group 1 (n = 75)

Group 2 (n = 75)

P Values

Group 1 (n = 75)

Group 2 (n = 75)

P Values

Insertions

0.33 ± 0.52

1.08 ± 1.9

< 0.001

0.23 ± 0.521

0.05 ± 1.1

< 0.001

0.34 ± 0.52

1.18 ± 1.9

< 0.001

Deletions

0.66 ± 0.82

1.2 ± 0.59

< 0.002

0.65 ± 0.22

1.1 ± 0.53

< 0.001

0.61 ± 0.20

1.0 ± 0.10

< 0.030

Transitions

1.8 ± 0.9

4.7 ± 2.0

< 0.001

1.7 ± 0.4

4.1 ± 1.0

< 0.003

2.0 ± 0.7

4.8 ± 1.6

< 0.015

Transversions

2.0 ± 2.5

2.5 ± 2.1

< 0.051

1.9 ± 0.5

2.4 ± 0.1

< 0.001

1.8 ± 0.3

1.8 ± 1.1

< 0.073

No. of mutation spots

6.2 ± 3.1

8.2 ± 4.2

< 0.043

3.1 ± 0.3

7.2 ± 4.0

< 0.002

9.2 ± 2.1

11.2 ± 4.2

< 0.004

Genetic distance

0.005 ± 0.24

0.13 ± 0.75

< 0.001

0.007 ± 0.31

0.11 ± 0.21

< 0.003

0.001 ± 0.25

0.17 ± 0.27

< 0.001

Non-synonymous substitution

0.07 ± 0.21

0.09 ± 0.13

< 0.050

0.007 ± 0.10

0.07 ± 0.03

< 0.001

0.15 ± 0.11

0.35 ± 0.14

< 0.031

Synonymous substitutions

0.005 ± 0.20

0.006 ± 0.01

< 0.053

0.001 ± 0.02

0.01 ± 0.01

< 0.031

0.004 ± 0.12

0.006 ± 0.12

< 0.030

  1. Group 1: Patients with SVR.
  2. Group 2: Non-responders.