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Table 1 Genetic diversity of all the three genomic regions (5′ UTR, core and NS5B) of HCV isolates for both treatment groups

From: Occurrence of genetic modifications in core, 5′UTR and NS5b of HCV associated with viral response to treatment

Factors 5′ UTR Core NS5B
Group 1 (n = 75) Group 2 (n = 75) P Values Group 1 (n = 75) Group 2 (n = 75) P Values Group 1 (n = 75) Group 2 (n = 75) P Values
Insertions 0.33 ± 0.52 1.08 ± 1.9 < 0.001 0.23 ± 0.521 0.05 ± 1.1 < 0.001 0.34 ± 0.52 1.18 ± 1.9 < 0.001
Deletions 0.66 ± 0.82 1.2 ± 0.59 < 0.002 0.65 ± 0.22 1.1 ± 0.53 < 0.001 0.61 ± 0.20 1.0 ± 0.10 < 0.030
Transitions 1.8 ± 0.9 4.7 ± 2.0 < 0.001 1.7 ± 0.4 4.1 ± 1.0 < 0.003 2.0 ± 0.7 4.8 ± 1.6 < 0.015
Transversions 2.0 ± 2.5 2.5 ± 2.1 < 0.051 1.9 ± 0.5 2.4 ± 0.1 < 0.001 1.8 ± 0.3 1.8 ± 1.1 < 0.073
No. of mutation spots 6.2 ± 3.1 8.2 ± 4.2 < 0.043 3.1 ± 0.3 7.2 ± 4.0 < 0.002 9.2 ± 2.1 11.2 ± 4.2 < 0.004
Genetic distance 0.005 ± 0.24 0.13 ± 0.75 < 0.001 0.007 ± 0.31 0.11 ± 0.21 < 0.003 0.001 ± 0.25 0.17 ± 0.27 < 0.001
Non-synonymous substitution 0.07 ± 0.21 0.09 ± 0.13 < 0.050 0.007 ± 0.10 0.07 ± 0.03 < 0.001 0.15 ± 0.11 0.35 ± 0.14 < 0.031
Synonymous substitutions 0.005 ± 0.20 0.006 ± 0.01 < 0.053 0.001 ± 0.02 0.01 ± 0.01 < 0.031 0.004 ± 0.12 0.006 ± 0.12 < 0.030
  1. Group 1: Patients with SVR.
  2. Group 2: Non-responders.