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Figure 4 | Virology Journal

Figure 4

From: Entecavir combined with furin inhibitor simultaneously reduces hepatitis B virus replication and e antigen secretion

Figure 4

Influences of ETV combined with CMK on the HBV replication and HBeAg secretion. HepG2.2.15 cells were regularly cultivated and treated with or without CMK (20 μmol/L) and/or ETV (30 nmol/L). Intracellular core-associated HBV DNA was detected using Southern blot analysis. Relaxed circular (RC) HBV DNA was the HBV genome, and single-stranded linear (SS) HBV DNA was the replication intermediates. Virion-related HBV DNA in culture medium was quantified using real-time fluorescent PCR. HBeAg and HBsAg were detected using enzyme-linked immunosorbent assay. A: ETV abrogated the HBV replication-enhancing effect of CMK. B: ETV combined with CMK reduced HBV replication and HBeAg secretion simultaneously. **P < 0.01.

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Virology Journal

ISSN: 1743-422X