Skip to main content

Advertisement

Table 1 Influenza peptide epitopes and immunization strains

From: Identification of swine influenza virus epitopes and analysis of multiple specificities expressed by cytotoxic T cell subsets

SLA tetramer peptide epitopes Immunization strains 1-5
1 2 3 4 5
SwIV candidate epitope Viral protein of origin AA position* in virus Nucleotide position* in virus A/swine/Den mark/101310- 1/2011(H1N1pdm09) A/swine/Denmark/101568-1/2011(H1pdmN2†) A/swine/Denmark/19126/1993 (H1N1) A/swine/Denmark/101490-3/2011(H1N1) A/swine/Denmark/1037-2/2011(H1N2†)
CTELKLSDY NP 44-52 130-156 + + CTELQ LSDY CTELQ LSDY CTELQ LSDY
GTEKLTITY PB2 623-531 1567-1593 + + + + +
SSSFSFGGF PB2 320-328 958-984 + + + + +
YVFVGTSRY HA 215-223 643-669 + + YVS VES SKY YVS VVS SKY YVS VVS SKY
  1. Comparison of influenza virus candidate epitope sequences within the different viral strains used for immunizations. (+) SwIV candidate epitope sequence is 100% conserved in the viral strain used for immunization. (*) Amino acid position relative to start codon in virus A/swine/Denmark/12687/2003, (†) reassortant swine influenza virus encoding a human-like N2 gene [21]. Amino acids in bold mark substitutions in the sequence within the immunization strain compared to the respective candidate epitopes used for tetramer analysis.