|
SLA tetramer peptide epitopes
|
Immunization strains 1-5
|
|---|
|
1
|
2
|
3
|
4
|
5
|
|---|
|
SwIV candidate epitope
|
Viral protein of origin
|
AA position* in virus
|
Nucleotide position* in virus
|
A/swine/Den mark/101310- 1/2011(H1N1pdm09)
|
A/swine/Denmark/101568-1/2011(H1pdmN2†)
|
A/swine/Denmark/19126/1993 (H1N1)
|
A/swine/Denmark/101490-3/2011(H1N1)
|
A/swine/Denmark/1037-2/2011(H1N2†)
|
|---|
|
CTELKLSDY
|
NP
|
44-52
|
130-156
|
+
|
+
|
CTELQ LSDY
|
CTELQ LSDY
|
CTELQ LSDY
|
|
GTEKLTITY
|
PB2
|
623-531
|
1567-1593
|
+
|
+
|
+
|
+
|
+
|
|
SSSFSFGGF
|
PB2
|
320-328
|
958-984
|
+
|
+
|
+
|
+
|
+
|
|
YVFVGTSRY
|
HA
|
215-223
|
643-669
|
+
|
+
|
YVS VES SKY
|
YVS VVS SKY
|
YVS VVS SKY
|
- Comparison of influenza virus candidate epitope sequences within the different viral strains used for immunizations. (+) SwIV candidate epitope sequence is 100% conserved in the viral strain used for immunization. (*) Amino acid position relative to start codon in virus A/swine/Denmark/12687/2003, (†) reassortant swine influenza virus encoding a human-like N2 gene [21]. Amino acids in bold mark substitutions in the sequence within the immunization strain compared to the respective candidate epitopes used for tetramer analysis.
