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Figure 9 | Virology Journal

Figure 9

From: Activation of Pro-survival CaMK4β/CREB and Pro-death MST1 signaling at early and late times during a mouse model of prion disease

Figure 9

A model for the activation of signaling pathways involved in neuronal survival and death during scrapie pathogenesis. Relative activation states of CaMK4β/CREB (red line) and MST1 (green line) signaling in scrapie-infected mice during disease progression, indicated in grey. Between 90 and 130 dpi, there is a switch from signaling involved in neuronal survival (activated CaMK4β/CREB) to that involved in neuronal death (activated MST1). Adapted from [72] (Figure 7).

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