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Figure 7 | Virology Journal

Figure 7

From: Activation of Pro-survival CaMK4β/CREB and Pro-death MST1 signaling at early and late times during a mouse model of prion disease

Figure 7

MST1 and FOXO3 are expressed to lower levels in scrapie-infected mice at 130 dpi. Targeted secondary analyses of the MST1 signaling pathway in brainstem-cerebellum, subcortical and cortical regions of scrapie-infected mice at 70, 90, 110, 130 dpi or at terminal stage of disease (TER; 155–190 dpi). (A) Levels of DLK, MKK7, JNK2, MST1, and FOXO3 in the brainstem-cerebellums of three scrapie-infected mice at each time point, normalized to those in the mock-infected mice, shown by color bars. (B) Protein levels in all macrodissected regions, normalized to those in mock-infected mice, shown as time series. Mean ± SD; n = 3 (Mean ± range for FOXO3 at 90 dpi [brainstem-cerebellum] and TER [brainstem-cerebellum, subcortical region]; n = 2). Error bars on the x-axes, range in time of onset of terminal disease. The differences in expression levels in scrapie- versus mock-infected mice were analyzed by two-tailed paired ratio t-test. *P < 0.05; **P < 0.01; ****P < 0.0001.

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