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Table 1 Comparison of viral load in lytic versus chronic infection of CD4 + T cell line C8166

From: Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line

SIVmac251/C8166

Lytic infection

Chronic infection

Percentage of infected cells1

25%

100%

Copy number2

0.3

2-3

Viruses in supernatant3

3

300

Provirus integration4

18%

n.d.5

  1. 1As determined by indirect immune peroxidase assay.
  2. 2Copies per SIV DNA as determined by proviral specific PCR.
  3. 3Particles per cell at one day after infection or medium exchange by means of PCR analysis.
  4. 4Halo-FISH analysis, integration into transcriptionally active matrix regions.
  5. 5 n.d. not detectable by Halo-FISH analysis.
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Virology Journal

ISSN: 1743-422X