Figure 5

Cellular responses in chronically SIV-infected T cells and reported involvement in stages in acute SIV/HIV-1 infection of susceptible cell types: putative contributions to cell survival. The perturbation of cellular processes known to be important for the early viral replication cycle (A) and activity of cell growth genes (B) is predicted to confer survival of chronically SIV-infected T cells. Affected genes are listed from microarrays of SIV-resistant T cells and are associated with their reported roles in the viral replication cycle. Alterations in mRNA levels were not observed in acutely infected cells at 24 h after infection. Abbreviations and symbols: * or ^# inferred by the ICF. Differentially (green circle or red circle) and non-differentially (○) expressed genes, suggested activity and regulator status. Cellular response 2- to 5-fold decrease (green circle) or increase (red circle); more than 5-fold decrease (two green circles) or increase (two red circles); (○) no significant change in mRNA level.