Figure 4

Treg depletion has no effect on viral clearance in spleen and liver of C57BL/6 DEREG mice. (A) Plaques developed after inoculation of sub-confluent mouse embryonic fibroblast (MEF) layers with spleen homogenates of infected mice obtained 40 h, 3 days and 7 days p.i. (B) Viral burden of the liver at the indicated time points. Data depicted shows geometric mean with 95% confidence interval of three pooled experiments with 3-5 mice per group. Limit of detection was determined by cell toxicity of low diluted homogenates for MEFs.