Table 1 Amino acid differences in the capsid proteins of the selected PanAsia-1 strains of FMDV serotype O
Capsid protein | Position* | Amino acid differences§ | Secondary structure£ | |||
|---|---|---|---|---|---|---|
| Â | Â | O/Tibet/CHA/6/99wt | O/Tibet/CHA/6/99tc | O/Fujian/CHA/9/99wt | O/Fujian/CHA/9/99tc | Â |
VP4 | 4008 | Ala (A) | Ser (S) | Ala (A) | Ala (A) | N-terminus |
VP2 | 2065 | His (H) | His (H) | Arg (R) | His (H) | B-B knob |
2079 | Tyr (Y) | Tyr (Y) | His (H) | His (H) | B-C loop, close to antigenic site 2 | |
2080 | Leu (L) | Gln (Q) | Leu (L) | Leu (L) | ||
2136 | Glu (E) | Gly (G) | Glu (E) | Glu (E) | E-F loop, close to antigenic site 2 | |
VP1 | 1041 | Lys (K) | Lys (K) | Lys (K) | Thr (T) | B-C loop, antigenic site 3 |
1045 | Lys (K) | Lys (K) | Lys (K) | Gln (Q) | ||
1083 | Glu (E) | Glu (E) | Glu (E) | Lys (K) | D-E loop | |
1095 | Glu (E) | Glu (E) | Glu (E) | Ala (A) | E-F loop | |
1139 | Ser (S) | Ser (S) | Ser (S) | Arg (R) | G-H loop, close to antigenic site 1 | |
1144 | Val (V) | Ala (A) | Val (V) | Val (V) | G-H loop, antigenic site 1 | |
1158 | Thr (T) | Ala (A) | Thr (T) | Thr (T) | ||
| Â | 1212 | Leu (L) | Ser (S) | Leu (L) | Leu (L) | C-terminus, antigenic site 1 |