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Table 1 Amino acid differences in the capsid proteins of the selected PanAsia-1 strains of FMDV serotype O

From: Effects of two amino acid substitutions in the capsid proteins on the interaction of two cell-adapted PanAsia-1 strains of foot-and-mouth disease virus serotype O with heparan sulfate receptor

Capsid protein Position* Amino acid differences§ Secondary structure£
   O/Tibet/CHA/6/99wt O/Tibet/CHA/6/99tc O/Fujian/CHA/9/99wt O/Fujian/CHA/9/99tc  
VP4 4008 Ala (A) Ser (S) Ala (A) Ala (A) N-terminus
VP2 2065 His (H) His (H) Arg (R) His (H) B-B knob
2079 Tyr (Y) Tyr (Y) His (H) His (H) B-C loop, close to antigenic site 2
2080 Leu (L) Gln (Q) Leu (L) Leu (L)
2136 Glu (E) Gly (G) Glu (E) Glu (E) E-F loop, close to antigenic site 2
VP1 1041 Lys (K) Lys (K) Lys (K) Thr (T) B-C loop, antigenic site 3
1045 Lys (K) Lys (K) Lys (K) Gln (Q)
1083 Glu (E) Glu (E) Glu (E) Lys (K) D-E loop
1095 Glu (E) Glu (E) Glu (E) Ala (A) E-F loop
1139 Ser (S) Ser (S) Ser (S) Arg (R) G-H loop, close to antigenic site 1
1144 Val (V) Ala (A) Val (V) Val (V) G-H loop, antigenic site 1
1158 Thr (T) Ala (A) Thr (T) Thr (T)
  1212 Leu (L) Ser (S) Leu (L) Leu (L) C-terminus, antigenic site 1
  1. *, Amino acid residues are denoted by a standard four-digit numbering system. The first digit represents the protein (VP4, VP2 or VP1) and the remaining three digits the amino acid position, numbered independently for each protein from the amino (N-) terminus to the carboxyl (C-) terminus.
  2. §, Three-letter amino acid codes are used (one-letter amino acid code is given in parentheses). The specific amino acid residues in the viral capsid proteins are shown in bold. His-2079 in O/Fujian/CHA/9/99wt and O/Fujian/CHA/9/99tc (bold and italics) is different from Tyr-2079 in the majority of sequences in the alignment of VP2 of PanAsia-1 viruses.
  3. £, secondary structure assignments are as described in references 39, 40 and references cited in 46.