Locations of the distinct amino acid residues in the FMDV capsid of (A) rHN/TAR6-VP0 and (B) rHN/FJ9-VP1. The crystallographic coordinates of O1BFS (missing the first 15 amino acid residues at the N-terminus of VP4) were used as templates, and 3D structures of one of the twelve pentamers were optimized using the SWISS-MODEL program[36–38]. The respective capsid proteins VP1–4 are represented as green, cyan, magenta, and blue (internal). The G-H loop of VP1 is highlighted in yellow. The RGD motif (residues 1145–1147, colored green), residues 2079, 2080 (colored red) and 2136 in VP2 of O/Tibet/CHA/6/99tc, as well as residues 1041, 1045, 1083 (colored red), 1095 and 1139 in VP1 of O/Fujian/CHA/9/99tc are displayed in the space-filling models.