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Figure 5 | Virology Journal

Figure 5

From: The CD8 Antiviral Factor (CAF) can suppress HIV-1 transcription from the Long Terminal Repeat (LTR) promoter in the absence of elements upstream of the CATATAA box

Figure 5

Transcription of TATA-TAR construct is suppressed by CAF. Reporter gene product (CAT) expression in cells pretreated with Hanks buffer (-CAF) or conditioned culture medium from a transformed CD8+ T cell line (+CAF) and transfected with a construct containing only the TATA box and TAR from HIV-1 LTR, in the presence or absence of the HSV-1 ICP0 protein. Transcription from the LTR was driven either by CMV-Tat (Panel A) or addition of PMA (Panel B) Results are representative of 2 independent experiments conducted in triplicate. *, p < 0.05.

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Virology Journal

ISSN: 1743-422X