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Table 1 Amino acid conservation of the NS1 NES region

From: Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication

Position

Consensus

Prevalence

Percentage

138

Phe

24424/25183

96,99%

139

Asp

15412/25183

61,20%

140

Arg

22525/25183

89,44%

141

Leu

24763/25183

98,33%

142

Glu

24916/25183

98,94%

143

Thr

22149/25183

87,95%

144

Leu

21822/25183

86,65%

145

Ile

16910/25183

67,15%

146

Leu

22655/25183

89,96%

147

Leu

25105/25183

99,69%

148

Arg

25099/25183

99,67%

149

Ala

25134/25183

99,81%

150

Phe

25092/25183

99,64%

  1. A consensus sequence for the region was derived by running 25183 NS1 sequences through the Analyze Sequence Variation (SNP) tool on the Influenza Research Database –website (http://www.fludb.org). Prevalence of each amino acid is indicated as a total number and percentage within all the analyzed sequences.