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Figure 1 | Virology Journal

Figure 1

From: Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication

Figure 1

The nuclear export signal of A/Udorn/72 NS1. A, schematic representation of A/Udorn/72 NS1 with the localization signals NLS1 (aa 35–41), NES (aa 138–146) and NLS2/NoLS (aa 219–232) indicated. B, sequence of A/Udorn/72 NS1 NES region and the mutations introduced into the NES sequence to create recombinant mutant viruses. C, molecular surface representation of the position of NES within the dimericA/Udorn/72 NS1 effector domain based on the crystal structure by Xia et al. [22] (PDB ID 3EE8). Amino acids of the NES consensus sequence are indicated in red. The figure was created using RasMol 2.7.3. program (http://rasmol.org/).

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Virology Journal

ISSN: 1743-422X