Mimivirus replication cycle in amoebas. (I) Phagocytosis. (II) Virus entry into a phagosome, followed by star-gate opening and viral membrane fusion (III). (VI) Viral seed is released in the amoeba cytoplasm and gives start to an early viral factory (V). After few hours, the viral factory grows and orchestrates the morphogenesis (VI) of the viral progeny, which are released by cell lysis. At the right, transmission electron microscopy of APMV at its different steps of the replication cycle.