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Figure 5 | Virology Journal

Figure 5

From: Effective suppression of Dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain

Figure 5

CPE following DENV infection of group I intron transformed C6 / 36 cells. C6/36 cells were transformed with the anti-DENV group I introns or mCherry expression plasmids, and challenged with DENV (MOI 0.1). Micrographs were taken at 6 dpi using an inverted phase microscope at 20× magnification. Representative infected cell cultures are shown. Cultures expressing functional αDENV-U143-ΔN Bax intron constructs exhibited no CPE while some degree of cytopathology was observed for αDENV -U143-FL and the negative control αDENV -ΔU143-ΔN Bax. αDENV-U143-ΔN Bax-D refers to the active intron-ΔN Bax construct that is linked to the DCV-IRES/mCherry configuration as shown in Figure 2.

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Virology Journal

ISSN: 1743-422X