CPE following DENV infection of group I intron transformed C6 / 36 cells. C6/36 cells were transformed with the anti-DENV group I introns or mCherry expression plasmids, and challenged with DENV (MOI 0.1). Micrographs were taken at 6 dpi using an inverted phase microscope at 20× magnification. Representative infected cell cultures are shown. Cultures expressing functional αDENV-U143-ΔN Bax intron constructs exhibited no CPE while some degree of cytopathology was observed for αDENV -U143-FL and the negative control αDENV -ΔU143-ΔN Bax. αDENV-U143-ΔN Bax-D refers to the active intron-ΔN Bax construct that is linked to the DCV-IRES/mCherry configuration as shown in Figure 2.